Some molecules are exclusively toxic to biological systems and classified as being non-essential, others are essential for life. Nevertheless, above certain threshold concentrations all compounds (including essential ones) become toxic. Homeostasis of essential elements and detoxification of non-essential elements are thus vital drivers of well-being, longevity and survival. The identification and characterization of these intricate pathways form the foundations of Toxicogenomics.
The exponential growth of available genetic sequences and the completion of numerous genome-sequencing projects have unveiled the next challenge: the rearrangement of vast amounts of data into functional and mechanistically meaningful units. The outcome will provide novel insights into pathogenesis, new methods of risk assessment, genetic risk-modifications in preventative medicine and new therapeutic targets for pharmaceutical and biological medicines.
By exploiting genomic, proteomic and toxicological tools within model species (the nematode C.elegans) as well as key environment organisms (the earthworm), we aim to expand the horizon of Toxicogenomics.
Rebecca Blackwood The atmosphere in the lab has been great and I have found everyone I work with to be very friendly and helpful, which was essential to me. I have certainly learnt a great deal...
Ralph Menzel Overall, I value Stephen’s professional and reliable personality. I consider him to be an outstanding scientist and communicator but equally also an organized, helpful and enthusiastic mentor...
Emma Moles Garcia Being part of this research team was a great experience. Stephen is a very approachable supervisor and I was able to count on the group and his support at all times...
